UN Secretary-General Antonio Guterres on Thursday painted a dark picture of the situation in the Middle East, warning that spiralling tensions over the war in Gaza and Iran's attack on Israel could devolve into a "full-scale regional conflict."

Guterres also said Israel's military offensive on Hamas militants in the Gaza Strip, in retaliation for their unprecedented October 7 attack, had created a "humanitarian hellscape" for civilians trapped in the besieged Palestinian territory.

His speech came hours before a vote in the Security Council on a Palestinian bid for full UN membership -- an initiative likely to fail, as the veto-wielding United States, Israel's main ally, has voiced its opposition.

"The Middle East is on a precipice. Recent days have seen a perilous escalation -- in words and deeds," Guterres told a high-level Council meeting with several foreign ministers present, including from Jordan and Iran.

"One miscalculation, one miscommunication, one mistake, could lead to the unthinkable -- a full-scale regional conflict that would be devastating for all involved," he said, calling on all parties to exercise "maximum restraint."

"Let me be clear: the risks are spiraling on many fronts. We have a shared responsibility to address those risks and pull the region back from the precipice."

Iran unleashed a barrage of missiles and drones on Israel over the weekend, after an attack on its consulate in Damascus widely blamed on Israel.

Israeli officials have not said when or where they would retaliate, but the country's military chief has vowed a response.

"It is high time to end the bloody cycle of retaliation," Guterres said. "It is high time to stop."