A violent clash between two groups of the Marri community claimed three lives in Khairpur, 24NewsHD TV channel reported on Monday.
Another two people sustained injuries in the deadly clash over a land dispute in a village in the Economic Zone police precincts.
A heavy contingent of police reached the site and besieged the area.
The bodies and injured were taken to the Civil Hospital.
According to police, they have launched a hunt for the culprits and are piecing together evidence.