Bairstow pulls out of Hundred to rest ahead of South Africa series
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England also have a congested post-season touring schedule, particularly for multi-format international such as Bairstow, with series in Pakistan, Australia, New Zealand and Bangladesh, in addition to the Twenty20 World Cup.
Bairstow, 32, was due to represent the Cardiff franchise Welsh Fire in the second season of the Hundred -- English domestic cricket's fledgling 100 balls per side competition -- with the side facing champions Southern Brave at Southampton on Wednesday.
"I'm really disappointed I won't be part of The Hundred this year," said Bairstow.
"All the best to the Welsh Fire men and women -- I'll be cheering you on."