Vega rocket launched from French Guiana
The coronavirus pandemic and persistent winds over the South American launch site also caused delays.
Vega successfully deployed 53 small satellites -- most weighing less than 15 kilogrammes (33 pounds) -- on behalf of clients from 13 countries.
"I hope these microsatellites enjoyed their ride on Europe's direct line to space!" Stephane Israel, chief executive of launch service provider Arianespace, wrote on Twitter.
Its last mission in July 2019 failed around two minutes after take-off because of an apparent structural failure that caused the launcher to split in two.
It was the first failed mission after 14 successful launches since it began operations in 2012.