Pakistan posts 62 more coronavirus cases, no death

Pfizer Covid vaccine for under-fives effective with three doses: Argentine president pays 'fine' for birthday dinner during Covid lockdown

By: News Desk
Published: 09:30 AM, 24 May, 2022
Pakistan coronavirus
Caption: A six-year-old child receives Pfizer-BioNTech Covid-19 Vaccine for 5-11 year old kids at Hartford Hospital in Hartford, Connecticut, US.–AFP
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Pakistan has registered another 62 coronavirus cases and no fatality during the last 24 hours (Monday), showed the figures released by the National Institute of Health Pakistan on Tuesday morning.

As per the latest NIH data, the death toll remained the same at 30,379, whereas the number of total infections now stood at 1,529,899 after adding the fresh 62 cases.

During the last 24 hours (Monday), 13,084 tests were conducted throughout Pakistan whereas the positivity ratio stood at 0.47 percent. The number of patients in critical care was recorded at 78.

Pfizer Covid vaccine for under-fives effective with three doses

The Pfizer-BioNTech Covid vaccine is safe and effective when given as three doses to children under five years, the companies said Monday, welcome news for parents of the only age group not yet eligible for immunization in most countries.

The announcement comes as the US Food and Drug Administration (FDA) is planning highly-anticipated meetings in the coming weeks to weigh authorization. 

In a clinical trial, Pfizer-BioNTech evaluated three doses, given at three micrograms, and found the vaccine evoked a strong immune response in children aged from six months through four years.

Side-effects were similar in the vaccine and placebo groups.

Vaccine efficacy was 80.3 percent, according to a preliminary estimate -- though this was based on very low numbers and may change significantly by the time of the final estimate.

"We are pleased that our formulation for the youngest children, which we carefully selected to be one-tenth of the dose strength for adults, was well tolerated and produced a strong immune response," said Pfizer CEO Albert Bourla in a statement.

"We look forward to soon completing our submissions to regulators globally with the hope of making this vaccine available to younger children as quickly as possible, subject to regulatory authorization," he added.

The FDA has tentatively scheduled three dates in June where experts will meet and likely decide whether to authorize the Pfizer Covid vaccine for under-fives and the Moderna vaccine for under-sixes, which is given as two shots of 25 micrograms.

The agency was originally set to evaluate the Pfizer vaccine given as two doses in February, but data showed it did not provoke a strong enough immune response in children aged two to four. The FDA then asked to see data for a third shot.

- Results welcomed -

In the latest study, 1,678 children received a third dose at a time when Omicron was the predominant variant.

An analysis of a subset of participants showed antibody levels were similar to 16- to 25-year-olds who were given the full strength vaccine at two doses.

No new adverse events were identified, and the majority of side effects were mild or moderate.

Three doses of the vaccine "appear to be very safe and highly effective in preventing not only severe disease, hospitalization, and death from Covid, but even symptomatic Covid at a time when Omicron was the dominant variant," Celine Gounder, editor-at-large for public health at Kaiser Health News told AFP.

"However, we know that protection against SARS-CoV-2 infection and milder symptomatic disease wanes over time," added Gounder, an infectious disease specialist and epidemiologist.

"Pfizer is reporting follow-up data only out to seven days after the third dose of vaccine. It's too early to say how the three-dose series would perform out to several months or a year."

Jeremy Faust, of Brigham and Women's Hospital Department of Emergency Medicine, told AFP: "My first impression is very positive. These numbers are exactly the kinds of signals we wanted to see."

"I wish the two-dose series had worked for Pfizer-BioNTech. It didn't. But the three-dose series appears to have given these very young children the protection we want them to have," the doctor added. 

If and when both Pfizer's and Moderna's vaccines are authorized, parents will have to consider whether they want their children to receive Moderna's two dose vaccine -- which will offer faster protection -- or Pfizer's three doses -- which will take longer to be effective but may ultimately be more protective.

As with adults, the first two doses of Pfizer's vaccine are given to under-fives three weeks apart, but then the third is given two months after the second. 

Severe disease from Covid is very rare among under-fives but can occur, with 477 US deaths in this age group since the start of the pandemic, or about 0.1 percent of all deaths.

Children can also contract a rare post-viral condition called multisystem inflammatory syndrome in children (MIS-C), which has affected some 8,210 US children and killed 68. 

Like adults, some children who get Covid may go on to develop long Covid, with new, ongoing or returning symptoms, including brain fog and fatigue.

Argentine president pays 'fine' for birthday dinner during Covid lockdown

Argentina's President Alberto Fernandez and the first lady on Monday paid a fine of three million pesos (about $24,000), in the form of a charitable donation, in return for legal proceedings against them being dropped over a birthday dinner during the pandemic lockdown that caused a scandal.

A federal judge approved the president's "economic compensation" proposal, in which he will pay 1.6 million pesos to a prestigious vaccine research institute, the Malbran Institute.

His partner, Fabiola Yanez, offered a donation of 1.4 million, which was also approved.

Prosecutors opened an investigation last year over suspected breaches of health protocols by the center-left leader, after leaked photos showed a birthday dinner for the first lady being hosted in July 2020 at the Quinta de Olivos, an official residence of the president in the Buenos Aires suburbs.

At that time, the capital was subject to a strict Covid-19 lockdown, with a ban on all gatherings -- even for funerals.

A contrite Fernandez, himself a professor of criminal law, had pleaded that it was "not a malicious act, but recklessness and negligence," calling it an "error, a slippage" in the context of a "pandemic management maelstrom."

The prosecutors symbolically fixed the reparations at the cost of a respiratory machine and a stay in intensive care.

According to some local media, the 63-year-old head of state will have to take out a bank loan in order to be able to pay the fine. 

The publication of a photo of the dinner, with a dozen guests, had triggered a deluge of criticism in the pandemic-hit country, and elicited rebukes from both Fernandez's own party as well as the opposition.

With inputs from AFP.

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