Residents reported heavy Israeli fire in central Gaza on Friday, with regional tensions soaring after Iran threatened reprisals over a strike in Syria this month that killed two Iranian generals.

As talks for a truce and hostage release dragged on, fears that Iran could soon launch an attack on Israel prompted the United States to announce it was sending reinforcements to the Middle East as a deterrent.

Mohammed al-Rayes, 61, told AFP that he fled Israeli "air strikes and artillery shelling" in Nuseirat, central Gaza overnight.

"It was all fire and destruction, with so many martyrs lying in the street," he said.

Another resident, Laila Nasser, 40, reported "shells and missiles" throughout the night.

"They will do to Nuseirat what they did to Khan Yunis," said Nasser, vowing to flee to the southernmost city of Rafah, like most of Gaza's population.

Israeli troops pulled out of the devastated city of Khan Yunis last week after months of heavy fighting, but officials said the move was in preparation for an assault on Hamas militants in Rafah.

Authorities in the Hamas-ruled territory reported dozens of new air strikes in Gaza's central region.

Israel's military said its aircraft had struck more than 60 militant targets in Gaza over the previous day.

The Hamas media office said 25 people were taken to hospital in Deir al-Balah city "as a result of an air strike on a house".

 'Shoulder to shoulder' 

 The war began with Hamas's unprecedented October 7 attack against Israel which resulted in the deaths of 1,170 people, mostly civilians, according to Israeli figures.

Israel's retaliatory offensive has killed at least 33,634 people in Gaza, mostly women and children, according to the territory's health ministry.

The latest bombardments in Gaza came after Israel said it had strengthened air defences and paused leave for combat units, following a deadly April 1 air strike that destroyed Iran's consulate building in Damascus.

Iran blamed its arch foe Israel, which has stepped up strikes against Iran-linked targets in Syria since the Gaza war began.

US President Joe Biden said Wednesday that Iran was "threatening to launch a significant attack" and sent the head of US Central Command, General Michael Kurilla, to Israel for urgent talks.

The White House said on Friday that the threat from Iran remained "real".

"We are moving additional assets to the region to bolster regional deterrence efforts and increase force protection for US forces," a Pentagon official said.

After meeting Kurilla on Friday, Defence Minister Yoav Gallant said Israel and the United States were "shoulder to shoulder" in facing the threat from Iran, despite recent differences over the conduct of the war in Gaza.

"Our enemies think that they can pull apart Israel and the United States, but the opposite is true -- they are bringing us together and strengthening our ties," Gallant said. "We stand shoulder to shoulder."

Washington, which has had no diplomatic relations with Tehran since the aftermath of the 1979 Islamic revolution, also asked its allies to use their influence with Iran to urge restraint, the State Department said.

After calls with his Australian, British and German counterparts Thursday, Foreign Minister Hossein Amir-Abdollahian said: "Iran does not seek to expand the scope of the war."

But he added that it felt it had no choice but to respond to the deadly attack on its diplomatic mission after the UN Security Council failed to take action.

  'Significant attack' 

 France warned its nationals against travelling to Iran, Israel, Lebanon or the Palestinian territories, after the US embassy in Israel announced it was restricting the movements of its diplomats over security fears.

German airline Lufthansa said its planes would no longer use Iranian airspace as it extended a suspension on flights to and from Tehran.

In their October attack, Hamas militants seized about 250 hostages, 129 of whom remain in Gaza, including 34 the Israeli army says are dead.

The European Union on Friday imposed sanctions on the armed wings of Hamas and Islamic Jihad for "widespread" sexual violence during the October 7 attack.

The bloc said fighters from the two militant groups -- already on the EU's terrorism blacklist -- "committed widespread sexual and gender-based violence systematically, using it as a weapon of war".

  New crossing for aid 

 Washington has ramped up pressure on Netanyahu to agree to a truce, increase aid flows and abandon plans to send troops into Rafah.

The Israeli army said Friday that an undisclosed number of aid trucks had been allowed to enter Gaza through a newly opened border crossing into the north of the territory.

"The first food aid trucks entered through the new northern crossing from Israel into Gaza yesterday," the Israeli defence ministry body that oversees Palestinian civil affairs, COGAT, said.

Despite repeated AFP requests for comment, Israeli authorities did not disclose how many trucks entered Thursday nor the exact location of the new crossing, which Israeli media reported to be close to the Zikim kibbutz.

Gallant had trumpeted the new crossing on Wednesday, promising to "flood Gaza with aid", but on Thursday the UN Security Council said "more should be done".

World Health Organization chief Tedros Adhanom Ghebreyesus said an assessment team that visited Khan Yunis found "destruction disproportionate to anything one can imagine" and three medical centres that were no longer functioning.

Truce talks which started on Sunday in Cairo have brought no breakthrough on a plan presented by US, Qatari and Egyptian mediators, which Hamas said it was studying.

The framework plan would halt fighting for six weeks and see the exchange of about 40 hostages for hundreds of Palestinian prisoners, as well as more aid deliveries.