Zverev pulls out of US Open with ankle injury
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He left the court at Roland Garros in a wheelchair and subsequently underwent surgery to repair three torn ligaments in his right ankle.
The German lost the 2020 US Open final to Dominic Thiem, having led by two sets, and reached the semi-finals last year.
He is still waiting for a maiden Grand Slam title, despite winning five Masters trophies and the ATP Finals twice.
His place in the main draw of the August 29-September 11 tournament will be taken by American Stefan Kozlov.
He has been named in Germany's team for the group stage of the Davis Cup finals next month.
Zverev might not be the only top-10 men's player absent from the year's final Grand Slam. Novak Djokovic is unlikely to be able to play because of his refusal to get vaccinated against Covid.
The 21-time major winner was forced out of last week's Cincinnati Masters and Montreal earlier this month for the same reason.