Tsitsipas wins five-set thriller to reach quarter-final
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Tsitsipas was staring at defeat trailing two sets to one before he fought back to beat the 20th seed Fritz 4-6, 6-4, 4-6, 6-3, 6-4 in 3hr 23min of classic late-night tennis on Rod Laver Arena.
The Greek world number four has now reached the quarter-finals for the third time and will face Italy's 11th seed Jannik Sinner, who accounted for Australia's Alex De Minaur in straight sets.
Tsitsipas is a two-time semi-finalist in Melbourne but is yet to win a Grand Slam title.
"It was an epic match. I gave everything out on the court today, I am very proud of myself with the way I fought and the way I stayed consistent in the moments that were close and crucial," Tsitsipas said.
"I am overwhelmed, it's too much, the stadium was on fire, it's too good to be true.
"I knew it was going to get physical and I kept reminding myself to get in there and do the work, don't give up, give it a little bit more patience and in the end it paid off."
He also holds the distinction of beating both Rafael Nadal and Roger Federer on his way to his two previous semi-final appearances at the Australian Open.