Israeli strikes targeting a part of Syria where fighters loyal to Lebanon's Hezbollah are based killed five people Wednesday, a war monitor said.

The Israeli missiles struck an area near three villages in the west of Homs province, said the Syrian Observatory for Human Rights, a Britain-based group with a wide network of sources on the ground.

Three Syrian soldiers as well as two Syrian militiamen affiliated with Hezbollah were killed in the early morning strikes, the monitoring organisation said.

The official Syrian news agency SANA, citing a military official, had reported earlier that two civilians had been killed and seven people injured in Israeli "aerial aggression".

Syria's air defences "repelled the aggression and shot down most" of the missiles, SANA said, quoting the same source.

The Israeli military, which rarely acknowledges individual strikes on Syria, declined to comment on "reports in the foreign media".

Israel has said repeatedly it will not allow neighbouring Syria to become a launchpad for its foe Iran.

Since civil war broke out in Syria in 2011, Israel has carried out hundreds of air strikes on Syrian territory, targeting government positions as well as allied Iran-backed forces and Hezbollah fighters.

SANA had reported on November 8 that two Syrian soldiers were injured by Israeli missile strikes on areas in the centre and the west of the country.

On October 30, five pro-Iranian militiamen were killed in an Israeli strike that destroyed Hezbollah and Iranian weapons and ammunition near the Syrian capital, the monitor said.

An Israeli strike in mid-October killed nine pro-government fighters near the T4 airbase east of Palmyra in central Syria, according to the same source.