News

Arthritis drug shows significant promise in severe COVID-19 cases: study

April 28, 2020 05:59 PM


Twitter Share Facebook Share WhatsApp Share

The arthritis drug tocilizumab has shown early promise in preventing extreme inflammation in gravely ill COVID-19 patients, according to a French clinical study.

The treatment, which suppresses the body's natural immune response, was found to reduce "significantly" the number of deaths or life support interventions compared with a control group of patients.

The study, carried out by the Paris university hospital trust (AP-HP), looked at 129 people hospitalised with moderate or severe viral pneumonia, which occurs in 5-10 percent of COVID-19 patients. Half received two injections of tocilizumab as well as standard treatment with antibiotics, while the control group received only standard treatment.

While the results are yet to be published, those involved in the research said it showed clear "clinical benefit" of tocilizumab treatment.

AP-HP said it had decided to publicise the study before publishing official results "for public health reasons".

They stressed however that further research was needed on the effectiveness of the drug and the potential for side effects. Tocilizumab, sold under the brand names Actemra and RoAcemtra, is commonly used to treat rheumatoid arthritis.

It is a lab-synthesised antibody that inhibits against a specific protein receptor involved in the body's natural immune response.

Researchers believe the drug might be able to stave off a state of heightened immune response known as cytokine storms -- where the body's reaction to a foreign body such as a disease or chemical creates acute inflammation.

Cytokine storms can be deadly and occur in severely ill COVID-19 patients. Tocilizumab currently costs around 800 euros ($870) per injection. Several existing drugs, including anti-viral medicines, are currently being trialled worldwide for COVID-19 treatment.

https://www.youtube.com/watch?v=pOavNaBX4NU


Most Read

  1. Public Holiday announced in Lahore tomorrow Public Holiday announced in Lahore tomorrow
  2. Nazish Jahangir to hit any marriage proposal from Babar Azam out of the ground Nazish Jahangir to hit any marriage proposal from Babar Azam out of the ground
  3. Iranian First Lady visits Numl Iranian First Lady visits Numl
  4. Madiha Rizvi ties the knot again Madiha Rizvi ties the knot again
  5. ‘Rs150m corruption scandal’ involving Marriyum Aurangzeb surfaces ‘Rs150m corruption scandal’ involving Marriyum Aurangzeb surfaces
  6. Zara Noor Abbas inspired by Rani Mukerji Zara Noor Abbas inspired by Rani Mukerji

Opinion

  1. Islamabad becoming the hub of international diplomacy
    Islamabad becoming the hub of international diplomacy

    By Salim Bokhari

  2. Insights into the Pakistan Stock Exchange's Recent Record High Triumph
    Insights into the Pakistan Stock Exchange's Recent Record High Triumph

    By Zulfiqar Ali Mir

  3. IMEC to sabotage CPEC
    IMEC to sabotage CPEC

    By Dr Asif Channer

  4. 1947 TO FORM 47
    1947 TO FORM 47

    By Dr Asif Channer

  5. Beijing wants to further highlight industrial sector in its country and take scientific innovation to new heights....
    Beijing wants to further highlight industrial sector in its country and take scientific innovation to new heights....

    By Ali Ramay

  6. Global race: China will reduce its unnecessary expenses
    Global race: China will reduce its unnecessary expenses

    By Ali Ramay