'Stop hurting us': Egypt's Sisi on Prophet cartoons
"People have the right to express what they have in mind... (but) I suppose this stops when the feelings of more than one and a half billion (Muslims) are hurt," he said.
"Please, stop hurting us," Sisi said in a televised address to mark the anniversary Thursday of the Prophet Mohammed's birthday.
"To insult the prophets amounts to underestimating the religious beliefs of many people," he added.
Sisi did not refer by name to French President Emmanuel Macron and his defence of the right to mock religion following the murder of a French schoolteacher over Prophet Mohammed cartoons he had shown in class.
Macron's comments have triggered protests and a call to boycott French goods in some Muslim-majority countries.
There was little sign of the call being heeded in Egypt despite boycott calls on social media.