Injured Marsh out of Australia's tour of Pakistan
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The 30-year-old all-rounder was expected to play a key role in the three-match ODI series but was ruled out ahead of Tuesday's first game, won by the visitors.
"Marsh will leave the Australian squad in Pakistan to continue his recovery from a low-grade hip flexor injury and would not be available for remaining three matches," Cricket Australia said in a statement.
"I am disappointed to miss the Pakistan series but look forward to rejoining the Australian squad for our next tour," Marsh said.
Australia were also hit by positive Covid-19 tests for two players -- Josh Inglis and Ashton Agar -- who will now also miss the on-going ODI series.
Australia lead the series 1-0 after a thumping 88-run win over Pakistan in the first match.
The remaining matches are on Thursday and Saturday, also in Lahore.
Australia will also play a single Twenty20 international in Lahore on April 5.