Injured Denly ruled out of Ireland ODI series
The 34-year-old missed England's opening six-wicket win on Thursday after suffering spasms in training on the eve of the match.
He has failed to recover and will be replaced in the squad by Liam Livingstone.
Denly lost his place in the England Test squad earlier this season after a poor performance in the first Test against the West Indies which the tourists won.
England came back to win the three match series 2-1.