EU sanctions 8 Iranian security officials over 2019 crackdown
The move to impose asset freezes and visa bans, effective immediately with publication in the bloc's official journal, comes at a sensitive time as Brussels mediates efforts to revive the nuclear deal between world powers and Tehran.
The listing said Guards commander Hossein Salami "bears responsibility for serious human rights violations".
Those under his command had "used lethal force to suppress the November 2019 protests in Iran, causing the deaths of and injuries to unarmed protesters", it said.
Three detention facilities where the EU alleged torture of detainees had taken place were put on the blacklist.
In November 2019 a surprise hike in fuel prices sparked a wave of protests across Iran, before they were put down amid a near-total internet blackout.
At least 304 people died in the unrest, according to London-based Amnesty International, while some authorities in Iran have announced 230 deaths during what they claimed were "riots".
The United Nations said there were mass arrests following the events of 2019, but no details have been released about how many were detained and how many are still held.
The decision to target the top Iranian officials was unveiled as negotiators in Vienna try to make progress on efforts to return the United States to the 2015 nuclear deal after former leader Donald Trump had Washington withdraw.
The EU on Friday described the talks as "constructive", with those involved looking to persuade Washington to drop swingeing sanctions reimposed by Trump and for Tehran to roll back breaches of the agreement.
US President Joe Biden has said he wants to revive the agreement, which places limits on the Islamic republic's nuclear programme in return for relief from biting economic sanctions.
But Tehran and Washington each insist the other side must make the first move.
A European diplomat told AFP that the decision on new sanctions had been in the pipeline for a long time and that it had been decided to press ahead with them despite it coinciding with the nuclear negotiations.