China's Wang Xiyu stuns third seed Sakkari at US Open
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Wang, ranked 75, came from a set down to knock out her Greek opponent, who made the semi-finals last year, 3-6, 7-5, 7-5 in their two-hour 43-minute clash.
The left-hander hit 35 winners and saved 12 of 17 break points and goes on to face either Alison Riske-Amritraj of the United States or Camila Osorio of Colombia for a place in the last 16.
Wang was one of four Chinese women to reach the second round in New York along with Zheng Qinwen, Zhang Shuai and Yuan Yue.